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Liposomal Delivery- What It Is And How It May Improve Your Health

Liposomal Supplements

With 85% of Americans suffering from malnutrition, science and research has spent over forty years examining and developing methods to increase the delivery of vital nutrients needed to keep the body healthy.

One such delivery system is called nano-emulsified liposomal delivery. It uses phospholipids to deliver nutrients to the cells more quickly and efficiently.

What are liposomes, you may be wondering? To understand liposomes, lipids must first be briefly discussed. Lipids can be made up of fatty acids, triglycerides, and cholesterol and are not able to be absorbed by water. All cells throughout the body have a lipid bilayer. This makes it possible for the distribution of liposomal delivery to a wide range of cells throughout the body. Lipids are beneficial for the role they play in maintaining the structure of membranes throughout the body.

With a better understanding of the role lipids play within the body, it’s now the phospholipids turn for definition. A phospholipid is a lipid with a phosphate group attached to it. Lecithin is an example of a phospholipid.

Now that we know what lipids and phospholipids are, what exactly are liposomes? Liposomes are small man made vesicles that transport phospholipids to cell membranes.

Liposomal delivery systems act as a transportation method to deliver specific nutrients, DNA, and even pharmaceutical medications to the cell more efficiently and effectively. Through the use of ultrasound technology, liposomes are created through a process called sonication. Sonication is the act of agitating a cell through sound frequencies set at 20 KHZ or greater. Sound waves help to combine phospholipids with a solution or whatever “molecule of interest” is required to increase a person’s nutrition status. Examples of nutrients that can be delivered through liposomal methods are vitamin D, C, or minerals, as well as compounds and nutraceuticals.

Absorption rate of liposomal supplements

The absorption rate of nano emulsified liposomal delivery has a significanty greater uptake capacity than the non liposomal B12, as seen in the chart. This study conducted by Dr. Christopher Shade, PhD, tests the absorption rates of vitamin B12. Three different uptake methods were measured and absorption rates were highest in the smallest liposomes, at the 53 nm, and lowest in the non-liposomal B12. The smaller the liposome, the quicker and more efficient the delivery is to certain cells such as endocrine glands as they are relatively small in size at 50-180 nm.

Normal vitamin B12 ranges are between 200-900 pg/ml (picograms per milliliter) and luckily, the majority of Americans get enough of this vitamin through diet. Vegans and octo-vegetarians should receive at least 200 milligrams to 250 of vitamin B12 per day.

It is important for individuals who are at risk of deficiency to understand that there is no scientific evidence to support the bioavailability and absorption rate of B12 in vegan food sources. With this understanding, supplementing with a sublingual or liposomal B12 could be beneficial.

Recent studies also confirm that food sources of vitamin B12 have a 50% less effective absorption rate than supplements. This makes liposomal delivery systems an excellent example of how supplementing may be beneficial when done smartly.

If you suspect a nutrient deficiency, scheduling an appointment with your MD to have a vitamin blood panel done can be beneficial. It is always important to speak with your doctor before starting any new supplement or dietary protocol.


Davinci Laboratories. (2020). What Does Liposomal Mean? Retrieved from

Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., Samiei, M., Kouhi, M., & Nejati-Koshki, K. (2013). Liposome: classification, preparation, and applications. Nanoscale research letters, 8(1), 102.

Shade C. W. (2016). Liposomes as Advanced Delivery Systems for Nutraceuticals. Integrative medicine (Encinitas, Calif.), 15(1), 33–36.,preventing%20breakdown%20by%20stomach%20acid.

Quicksilver Scientific. (2021). Retrieved from

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